反应详情

Following procedures of example 14, (S)-benzyl-2-(8-bromoimidazo[1,2-a]pyridin-2-yl)pyrrolidine-1-carboxylate (0.250 g, 0.62 mmol), o-tolyl boronic acid (0.1101 g, 0.81 mmol), potassium carbonate (0.1292 g, 0.93 mmol), and tetrakis(triphenylphosphine)palladium(0) (0.0360 g, 0.03 mmol) were reacted to give crude (2S)-benzyl 2-(8-o-tolylimidazo[1,2-a]pyridin-2-yl)pyrrolidine-1-carboxylate. The crude material was adsorbed onto silica gel and purified by flash chromatography (4 g SiO2, 0-70% ethyl acetate in hexanes) to give the final product (0.247 g, 0.60 mmol, 74%).

1. customwere reacted
2. customto give crude (2S)-benzyl 2-(8-o-tolylimidazo[1,2-a]pyridin-2-yl)pyrrolidine-1-carboxylate
3. custompurified by flash chromatography (4 g SiO2, 0-70% ethyl acetate in hexanes)