Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Cyanide | HCID 8929 | — |
| Reactant | HCID 24753198 | HCID 24753198 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 24753373 | HCID 24753373 | 80% |
Reaction Steps
A mixture of 8 (100 mg, 0.24 mmol) and NaCN (117 mg, 2.4 mmol) in DMSO (2 mL) was stirred at 120° C. for 2 h. The reaction mixture was cooled and freeze-dried overnight. The crude product was purified by column chromatography (CH2Cl2: EtOAc 10:1) to yield 9 (71 mg, 80%) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08063221B2 |
|---|
| Source dataset | uspto-grants-2011_11 |
|---|
| ORD ID | ord-8d4c8c40ff064618b3f2720b1e7c6131 |
|---|
| Source note | uspto-grants-2011_11 |
|---|
