HCID 59002836, compound → HCID 59002990, compound

Participants

Reaction Steps

A solution of ethyl 6,7-difluoro-1,4-dihydro-8-methoxy-5-nitro-4-oxoquinoline-3-carboxylate (1.50 g, 4.57 mmol) and 10% Pd/C (40.5 mg) in DMF (20 mL) was stirred under hydrogen atmosphere at room temprature for 14 h. The catalyst was removed by filtration over Celite and the filtrate was concentrated in vacuo. The resulting solid was recrystallized by EtOH, and dried to yield ethyl 5-amino-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxoquinoline-3-carboxylate (735 mg, 54%) as a pale brown solid.

Provenance & Evidence