反应详情

A solution of ethyl 6,7-difluoro-1,4-dihydro-8-methoxy-5-nitro-4-oxoquinoline-3-carboxylate (1.50 g, 4.57 mmol) and 10% Pd/C (40.5 mg) in DMF (20 mL) was stirred under hydrogen atmosphere at room temprature for 14 h. The catalyst was removed by filtration over Celite and the filtrate was concentrated in vacuo. The resulting solid was recrystallized by EtOH, and dried to yield ethyl 5-amino-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxoquinoline-3-carboxylate (735 mg, 54%) as a pale brown solid.

1. customThe catalyst was removed by filtration over Celite
2. concentrationthe filtrate was concentrated in vacuo
3. customThe resulting solid was recrystallized by EtOH
4. customdried