反应详情

A solution of ethyl 5-amino-1-benzyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxoquinoline-3-carboxylate (601 mg, 1.55 mmol) and 1M aq. NaOH (4.5 mL) in EtOH (10 mL) was stirred at 50° C. for 1 h. The solvent was removed and the residue was dissolved in water. The solution was acidified to pH 7 with 2M HCl and the resulting precipitate was removed by filtration, washed with water, EtOH and dried to yield 5-amino-1-benzyl-6,7-difluoro-1,4-dihydro-8-methoxy-4-oxoquinoline-3-carboxylic acid (480 mg, 85%) as a pale yellow solid.

1. customThe solvent was removed
2. dissolutionthe residue was dissolved in water
3. customthe resulting precipitate was removed by filtration
4. washwashed with water, EtOH
5. customdried