反应详情

Trifluoroacetic acid (26.3 mL, 342 mmol) was added to a solution of tert-butyl 4-[2-(trifluoromethyl)phenoxy]piperidine-1-carboxylate (29.5 g, 85 mmol) in CH2Cl2 (171 mL). The mixture was stirred at room temperature for 16 h. The solvent was removed by evaporation. The residue was diluted with EtOAc (200 mL), washed with 2 N NaOH (3×100 mL), brine, dried over Na2SO4, and evaporated to give the title compound as an oil.

1. customThe solvent was removed by evaporation
2. additionThe residue was diluted with EtOAc (200 mL)
3. washwashed with 2 N NaOH (3×100 mL), brine
4. dry with materialdried over Na2SO4
5. customevaporated