反应详情

温度

80 °C

A mixture of methyl 2-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}-1,3-thiazole-5-carboxylate (16 g, 41.4 mmol) and 1 N NaOH (85 mL, 85 mmol) in THF/MeOH (1:1) (v/v) (300 mL) was heated at 80° C. bath for 1 h. Volatile solvents were removed in vacuo. The residue was diluted with H2O, acidified with 1 N HCl (2.2 equiv) and extracted with EtOAc. The EtOAc extract was washed with H2O, dried (Na2SO4) and concentrated to give the title compound as a white solid.

1. customVolatile solvents were removed in vacuo
2. additionThe residue was diluted with H2O
3. extractionextracted with EtOAc
4. extractionThe EtOAc extract
5. washwas washed with H2O
6. dry with materialdried (Na2SO4)
7. concentrationconcentrated