Hydroxyamine hydrochloride → 5-[4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl]-N'-hydroxy-1,3,4-thiadiazole-2-carboximidamide

HRID 561225Notes

Reaction equation

[Br:1][C:2]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:3]=1[O:4][CH:5]1[CH2:10][CH2:9][N:8]([C:11]2[S:15][C:14]([C:16]#[N:17])=[N:13][N:12]=2)[CH2:7][CH2:6]1.Cl.[NH2:24][OH:25]>>[Br:1][C:2]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:3]=1[O:4][CH:5]1[CH2:6][CH2:7][N:8]([C:11]2[S:15][C:14]([C:16](=[N:24][OH:25])[NH2:17])=[N:13][N:12]=2)[CH2:9][CH2:10]1

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 533885275-[4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl]-1,3,4-thiadiazole-2-carbonitrile

Product 1

HCID 1363601515-[4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl]-N'-hydroxy-1,3,4-thiadiazole-2-carboximidamide

Procedure

The title compound was prepared in a similar manner as described for Example 7, step 2 from 5-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,3,4-thiadiazole-2-carbonitrile and hydroxylamine hydrochloride.

Sources & evidence

ORD record: ord-b72dd1399d984ad7a019efda6aa2e312
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08063224B2

Reaction notes

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