Sodium hydride → HCID 66696822, compound

HRID 561229Notes

Reaction equation

HRID 561229 reaction equation
[Br:1][C:2]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:3]=1[O:4][CH:5]1[CH2:10][CH2:9][N:8]([C:11]2[N:15]=[C:14]([C:16]3[CH:20]=[CH:19][NH:18][N:17]=3)[O:13][N:12]=2)[CH2:7][CH2:6]1.[H-].[Na+].Br[CH2:29][CH2:30][C:31]([O:33][CH2:34][CH3:35])=[O:32]>>[Br:1][C:2]1[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:3]=1[O:4][CH:5]1[CH2:10][CH2:9][N:8]([C:11]2[N:15]=[C:14]([C:16]3[CH:20]=[CH:19][N:18]([CH2:29][CH2:30][C:31]([O:33][CH2:34][CH3:35])=[O:32])[N:17]=3)[O:13][N:12]=2)[CH2:7][CH2:6]1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 68320Ethyl 3-bromopropionateHCID 178505487HCID 178505487, compound

Product 1

HCID 66696822HCID 66696822, compound

Procedure

The title compound was prepared in a similar manner as described in Example 7 (step 4) from 4-(2-bromo-5-fluorophenoxy)-1-[5-(1H-pyrazol-3-yl)-1,2,4-oxadiazol-3-yl]piperidine, sodium hydride and ethyl 3-bromopropionate and obtained as the more polar major isomer.

Workup

  1. customobtained as the more polar major isomer

Sources & evidence

ORD record
ord-4b4fffb533d4432d9bc73a48febd7523
Source dataset
uspto-grants-2011_11
Patent number
US08063224B2

Reaction notes

Loading…