HCID 66999491, compound → HCID 66999316, compound

HRID 561242Notes

Reaction equation

HRID 561242 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]([OH:26])([C@H:16]([N:18]1[CH:22]=[C:21]([N+:23]([O-])=O)[CH:20]=[N:19]1)[CH3:17])[CH2:10][N:11]1[CH:15]=[N:14][CH:13]=[N:12]1>CO.[Pd]>[NH2:23][C:21]1[CH:20]=[N:19][N:18]([C@H:16]([CH3:17])[C@:9]([C:3]2[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=2[F:1])([OH:26])[CH2:10][N:11]2[CH:15]=[N:14][CH:13]=[N:12]2)[CH:22]=1

Participants

4

Reactant 1

HCID 66999491HCID 66999491, compound

Product 1

HCID 66999316HCID 66999316, compoundYield 87%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

(2R,3R)-2-(2,4-difluorophenyl)-3-(4-nitro-1H-pyrazol-1-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol obtained in Step 1 (0.2 g, 0.55 mmol) was dissolved in methanol (15 mL) and 5% palladium on charcoal (5% Pd/C, 0.02 g) was added thereto, and the resulting mixture was stirred for 4 hours under a hydrogen atmosphere. The reaction solution was filtered through celite and the filtrate was concentrated by evaporation under a reduced pressure to obtain the title compound (0.16 g, yield 87%).

Workup

  1. filtrationThe reaction solution was filtered through celite
  2. concentrationthe filtrate was concentrated by evaporation under a reduced pressure

Sources & evidence

ORD record
ord-7e3485ae04124ab0bbb03a15269ec089
Source dataset
uspto-grants-2011_11
Patent number
US08063229B2

Reaction notes

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