HCID 59717983, compound → HCID 59717968, compound

HRID 561337Notes

Reaction equation

HRID 561337 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][S:15]([C:18]2[C:27]3[C:22](=[C:23]([C:28](=[O:37])[NH:29][CH:30]4[CH2:35][CH2:34][CH2:33][CH2:32][CH:31]4[CH3:36])[CH:24]=[CH:25][CH:26]=3)[CH:21]=[CH:20][CH:19]=2)(=[O:17])=[O:16])[CH2:10][CH2:9]1)=O)(C)(C)C>Cl.O1CCOCC1>[CH3:36][CH:31]1[CH2:32][CH2:33][CH2:34][CH2:35][CH:30]1[NH:29][C:28]([C:23]1[C:22]2[C:27](=[C:18]([S:15](=[O:17])(=[O:16])[NH:14][CH:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)[CH:19]=[CH:20][CH:21]=2)[CH:26]=[CH:25][CH:24]=1)=[O:37]

Participants

3

Reactant 1

HCID 59717983HCID 59717983, compound

Product 1

HCID 59717968HCID 59717968, compoundYield 120.1%

Reagents, catalysts & solvents 1

HCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

4-[5-(2-Methyl-cyclohexylcarbamoyl)-naphthalene-1-sulfonylamino]-piperidine-1-carboxylic acid tert-butyl ester 47 (380 mg) was dissolved in 4N HCl/dioxane (10 mL) and stirred for 3 hours at room temperature. Concentration in vacuo afforded 48 (370 mg) as its hydrochloride salt that was used without further purification. LC/MS m/z 430 (M+H)+.

Workup

  1. concentrationConcentration in vacuo

Sources & evidence

ORD record
ord-cedbc0335b53410e80872060e39ae8e6
Source dataset
uspto-grants-2011_11
Patent number
US08063222B2

Reaction notes

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