Sodium Hydroxide → HCID 45117210, compound

HRID 561346Notes

Reaction equation

HRID 561346 reaction equation
[OH-:1].[Na+].C([O:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([C:16]([CH3:18])=[CH2:17])[CH:11]=1)(=O)CC.O1CCOC[CH2:20]1>>[C:16]([C:12]1[CH:11]=[C:10]([CH:9]([CH3:20])[C:8]([OH:7])=[O:1])[CH:15]=[CH:14][CH:13]=1)([CH3:18])=[CH2:17]

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 312751,4-DioxaneHCID 66999255HCID 66999255, compound

Product 1

HCID 45117210HCID 45117210, compound

Procedure

1N NaOH (5 ml) was added to a solution of the ester in dioxan (5 ml) and the solution is stirred at r.t. overnight. After evaporation of the organic solvent, the mixture is acidified to pH=2 with 2N HCl until complete precipitation of the product, which is isolated, as a white solid by filtration.

Workup

  1. customAfter evaporation of the organic solvent
  2. customthe mixture is acidified to pH=2 with 2N HCl until complete precipitation of the product
  3. customwhich is isolated, as a white solid by filtration

Sources & evidence

ORD record
ord-6c71b272e5f64896841a24016ed5d907
Source dataset
uspto-grants-2011_11
Patent number
US08063242B2

Reaction notes

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