Phenethylamine → 4-Fluoro-3-[5-(phenethylaminomethyl)pyridin-2-yl]benzamide

HRID 561360Notes

Reaction equation

HRID 561360 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][C:3]=1[C:11]1[CH:16]=[CH:15][C:14]([CH:17]=O)=[CH:13][N:12]=1.[CH2:19]([NH2:27])[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][C:3]=1[C:11]1[CH:16]=[CH:15][C:14]([CH2:17][NH:27][CH2:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[CH:13][N:12]=1

Participants

3

Reactant 2

HCID 1001PhenethylamineHCID 595448574-Fluoro-3-(5-formylpyridin-2-yl)benzamide

Product 1

HCID 252165794-Fluoro-3-[5-(phenethylaminomethyl)pyridin-2-yl]benzamide

Procedure

Using the method outlined in Example 60, 4-fluoro-3-(5-formylpyridin-2-yl)benzamide (Preparation 13) and phenethylamine were converted to the title compound: RT=2.30 min; m/z (ES+)=350.0 [M+H]+.

Sources & evidence

ORD record
ord-cd6b47b754804febb5f485c6bdd93f4b
Source dataset
uspto-grants-2011_11
Patent number
US08063247B2

Reaction notes

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