反应详情

16.36 g (69.9 mmol) of 2-fluoro-6-nitrobenzyl bromide were introduced into 410 ml of THF, 5.88 g (83.9 mmol) of sodium methanethiolate were added in portions, and the mixture was stirred at RT for 24 h. The solid was filtered off and the filtrate was freed of solvent in a rotary evaporator. The residue was purified by flash chromatography (mobile phase: cyclohexane/ethyl acetate 10/1) to result in 11.43 g (81% of theory) of the title compound.

1. additionwere added in portions
2. filtrationThe solid was filtered off
3. customthe filtrate was freed of solvent in a rotary evaporator
4. customThe residue was purified by flash chromatography (mobile phase: cyclohexane/ethyl acetate 10/1)