反应详情

10.0 g (46.3 mmol) of 2-nitrobenzyl bromide were introduced into 100 ml of DMF at 0° C., 3.89 g (46.3 mmol) of sodium ethanethiolate were added in portions, and the mixture was stirred at RT for 4 h. It was diluted with water and extracted with ethyl acetate, and the organic phase was dried over magnesium sulfate, filtered and concentrated. The residue was purified by flash chromatography (mobile phase: cyclohexane/ethyl acetate 9/1) to result in 7.40 g (81% of theory) of the title compound.

1. extractionextracted with ethyl acetate
2. dry with materialthe organic phase was dried over magnesium sulfate
3. filtrationfiltered
4. concentrationconcentrated
5. customThe residue was purified by flash chromatography (mobile phase: cyclohexane/ethyl acetate 9/1)