Sodium methanethiolate → HCID 58392173, compound

HRID 561369Notes

Reaction equation

HRID 561369 reaction equation
Br[CH2:2][C:3]1[CH:8]=[C:7]([F:9])[CH:6]=[CH:5][C:4]=1[N+:10]([O-:12])=[O:11].[CH3:13][S-:14].[Na+]>O1CCCC1>[F:9][C:7]1[CH:6]=[CH:5][C:4]([N+:10]([O-:12])=[O:11])=[C:3]([CH2:2][S:14][CH3:13])[CH:8]=1

Participants

4

Reactant 2

HCID 4378561Sodium methanethiolateHCID 105616432-(Bromomethyl)-4-fluoro-1-nitrobenzene

Product 1

HCID 58392173HCID 58392173, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

10.0 g (42.7 mmol) of the compound from Example 1A were introduced into 100 ml of tetrahydrofuran at RT, 3.29 g (47.0 mmol) of sodium methanethiolate were added, and the mixture was stirred at RT for 4 h. It was filtered with suction through kieselguhr and washed with tetrahydrofuran, and the filtrate was concentrated to result in 9.00 g (100% of theory) of the title compound which were reacted without further purification.

Workup

  1. filtrationIt was filtered with suction through kieselguhr
  2. washwashed with tetrahydrofuran
  3. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-4f68edfe6bff4687b8c9dabba4feb95f
Source dataset
uspto-grants-2011_11
Patent number
US08063234B2

Reaction notes

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