4-(Trifluoromethyl)benzaldehyde → 2,2-Dimethyl-5-({6-fluoro-7-[(methylsulfanyl)methyl]-1H-indol-3-yl}[4-(trifluoromethyl)phenyl]methyl)-1,3-dioxane-4,6-dione

HRID 561386Notes

Reaction equation

HRID 561386 reaction equation
FC1C(CSC)=C2C(C=CN2)=CC=1.[F:14][C:15]([F:25])([F:24])C1C=CC(C=O)=CC=1.Cl[C:27]1[CH:32]=[CH:31][C:30]([CH:33]([C:44]2[C:52]3[C:47](=[C:48]([CH2:54][S:55][CH3:56])[C:49]([F:53])=[CH:50][CH:51]=3)[NH:46][CH:45]=2)[CH:34]2[C:39](=[O:40])[O:38][C:37]([CH3:42])([CH3:41])[O:36][C:35]2=[O:43])=[CH:29][CH:28]=1>>[CH3:41][C:37]1([CH3:42])[O:38][C:39](=[O:40])[CH:34]([CH:33]([C:44]2[C:52]3[C:47](=[C:48]([CH2:54][S:55][CH3:56])[C:49]([F:53])=[CH:50][CH:51]=3)[NH:46][CH:45]=2)[C:30]2[CH:31]=[CH:32][C:27]([C:15]([F:25])([F:24])[F:14])=[CH:28][CH:29]=2)[C:35](=[O:43])[O:36]1

Participants

4

Reactant 3

HCID 679964-(Trifluoromethyl)benzaldehydeHCID 583922596-Fluoro-7-[(methylsulfanyl)methyl]-1H-indoleHCID 583925085-[(4-Chlorophenyl){6-fluoro-7-[(methylsulfanyl)methyl]-1H-indol-3-yl}methyl]-2,2-dimethyl-1,3-dioxane-4,6-dione

Product 1

HCID 583921882,2-Dimethyl-5-({6-fluoro-7-[(methylsulfanyl)methyl]-1H-indol-3-yl}[4-(trifluoromethyl)phenyl]methyl)-1,3-dioxane-4,6-dione

Procedure

The title compound is prepared starting from 2.00 g (10.24 mmol) of the compound from Example 9A and 1.78 g (10.24 mmol) of 4-(trifluoromethyl)benzaldehyde in analogy to the synthesis of the compound from Example 21A. 3.83 g (75% of theory) of the title compound were obtained.

Workup

  1. customThe title compound is prepared

Sources & evidence

ORD record
ord-226503df199a4aa6aa1a46165463ba10
Source dataset
uspto-grants-2011_11
Patent number
US08063234B2

Reaction notes

Loading…