HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(Trifluoromethyl)benzaldehyde → 2,2-Dimethyl-5-({6-fluoro-7-[(methylsulfanyl)methyl]-1H-indol-3-yl}[4-(trifluoromethyl)phenyl]methyl)-1,3-dioxane-4,6-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(Trifluoromethyl)benzaldehyde | HCID 67996 | — |
| Reactant | 6-Fluoro-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392259 | — |
| Reactant | 5-[(4-Chlorophenyl){6-fluoro-7-[(methylsulfanyl)methyl]-1H-indol-3-yl}methyl]-2,2-dimethyl-1,3-dioxane-4,6-dione | HCID 58392508 | — |
| Product | 2,2-Dimethyl-5-({6-fluoro-7-[(methylsulfanyl)methyl]-1H-indol-3-yl}[4-(trifluoromethyl)phenyl]methyl)-1,3-dioxane-4,6-dione | HCID 58392188 | — |
Reaction Steps
The title compound is prepared starting from 2.00 g (10.24 mmol) of the compound from Example 9A and 1.78 g (10.24 mmol) of 4-(trifluoromethyl)benzaldehyde in analogy to the synthesis of the compound from Example 21A. 3.83 g (75% of theory) of the title compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063234B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-226503df199a4aa6aa1a46165463ba10 |
| Source note | uspto-grants-2011_11 |