反应详情

7.7 ml (7.65 mmol) of a 1N cyclopropylmagnesium bromide solution in THF were added to 1.09 g (5.10 mmol) of the compound from Example 121A in 19 ml of diethyl ether, and the mixture was stirred at RT overnight. A further 7.7 ml (7.65 mmol) of a 1N cyclopropylmagnesium bromide solution in THF were added, and the mixture was stirred at RT overnight. The reaction mixture was added to ice-water and extracted with dichloromethane, the organic phase was dried over magnesium sulfate, filtered and concentrated, and the crude product was purified by preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient) to result in 326 mg (33% of theory) of the title compound.

1. stirringthe mixture was stirred at RT overnight
2. extractionextracted with dichloromethane
3. dry with materialthe organic phase was dried over magnesium sulfate
4. filtrationfiltered
5. concentrationconcentrated
6. customthe crude product was purified by preparative HPLC (RP18 column; mobile phase: acetonitrile/water gradient)