反应详情

温度

40 °C

61.0 mg (1.62 mmol) of sodium borohydride were added to 300 mg (1.48 mmol) of the compound from Example 131A in 30 ml of ethanol and 13 ml of ethyl acetate under argon, and the mixture was stirred at 40° C. for 1 h. The reaction mixture was added to saturated aqueous ammonium chloride solution and ethyl acetate, the phases were separated, the aqueous phase was extracted twice with ethyl acetate, and the combined organic phases were dried over magnesium sulfate, filtered and concentrated. 280 mg (92% of theory) of a mixture of the diastereomers of the title compound were obtained.

1. customthe phases were separated
2. extractionthe aqueous phase was extracted twice with ethyl acetate
3. dry with materialthe combined organic phases were dried over magnesium sulfate
4. filtrationfiltered
5. concentrationconcentrated
6. addition280 mg (92% of theory) of a mixture of the diastereomers of the title compound
7. customwere obtained