HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-4-fluorobenzene → (4-Chloro-3-fluorophenyl)(4-fluorophenyl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-4-fluorobenzene | HCID 9993 | — |
| Reactant | 4-Chloro-3-Fluorobenzaldehyde | HCID 2724985 | — |
| Reactant | (4-Chlorophenyl)(4-methoxyphenyl)methanol | HCID 2757631 | — |
| Product | (4-Chloro-3-fluorophenyl)(4-fluorophenyl)methanol | HCID 2757452 | — |
Reaction Steps
The title compound was prepared starting from 5.00 g (28.57 mmol) of 4-fluorobromobenzene and 5.44 g (34.29 mmol) of 3-fluoro-4-chlorobenzaldehyde in analogy to the synthesis of the compound from Example 175A. 5.01 g (69% of theory) of the title compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063234B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-07e23b0d43db4bc6ba9eaeaef5352827 |
| Source note | uspto-grants-2011_11 |