1-Bromo-2,4-difluorobenzene → (4-Chloro-2-fluorophenyl)(2,4-difluorophenyl)methanol

HRID 561504Notes

Reaction equation

HRID 561504 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1Br.[Cl:10][C:11]1[CH:18]=[CH:17][C:14]([CH:15]=[O:16])=[C:13]([F:19])[CH:12]=1.ClC1C=CC(C(C2C=CC(OC)=CC=2)O)=CC=1>>[Cl:10][C:11]1[CH:18]=[CH:17][C:14]([CH:15]([C:3]2[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=2[F:1])[OH:16])=[C:13]([F:19])[CH:12]=1

Participants

4

Reactant 3

HCID 676741-Bromo-2,4-difluorobenzeneHCID 27249084-Chloro-2-fluorobenzaldehydeHCID 2757631(4-Chlorophenyl)(4-methoxyphenyl)methanol

Product 1

HCID 58392225(4-Chloro-2-fluorophenyl)(2,4-difluorophenyl)methanol

Procedure

The title compound was prepared starting from 5.00 g (25.91 mmol) of 2,4-difluorobromobenzene and 4.93 g (31.09 mmol) of 4-chloro-2-fluorobenzaldehyde in analogy to the synthesis of the compound from Example 175A. 3.34 g (47% of theory) of the title compound were obtained.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-b1b14cea67484719b4776e51c494ef8a
Source dataset
uspto-grants-2011_11
Patent number
US08063234B2

Reaction notes

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