HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-2,4-difluorobenzene → (4-Chloro-2-fluorophenyl)(2,4-difluorophenyl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-2,4-difluorobenzene | HCID 67674 | — |
| Reactant | 4-Chloro-2-fluorobenzaldehyde | HCID 2724908 | — |
| Reactant | (4-Chlorophenyl)(4-methoxyphenyl)methanol | HCID 2757631 | — |
| Product | (4-Chloro-2-fluorophenyl)(2,4-difluorophenyl)methanol | HCID 58392225 | — |
Reaction Steps
The title compound was prepared starting from 5.00 g (25.91 mmol) of 2,4-difluorobromobenzene and 4.93 g (31.09 mmol) of 4-chloro-2-fluorobenzaldehyde in analogy to the synthesis of the compound from Example 175A. 3.34 g (47% of theory) of the title compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063234B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-b1b14cea67484719b4776e51c494ef8a |
| Source note | uspto-grants-2011_11 |