Ethyl 3-{6-fluoro-7[(methylsulfanyl)methyl]-1H-indol-3-yl}-3-[4-(trifluoromethyl)phenyl]propanoate → 3-{6-Fluoro-7-[(methylsulfanyl)methyl]-1H-indol-3-yl}-3-[4-(trifluoromethyl)phenyl]propan-1-ol

HRID 561528Notes

Reaction equation

HRID 561528 reaction equation
[F:1][C:2]1[C:10]([CH2:11][S:12][CH3:13])=[C:9]2[C:5]([C:6]([CH:14]([C:21]3[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][CH:22]=3)[CH2:15][C:16](OCC)=[O:17])=[CH:7][NH:8]2)=[CH:4][CH:3]=1.ClC1C=CC(C(C2C3C(=C(CSC)C(F)=CC=3)NC=2)CCO)=CC=1>>[F:1][C:2]1[C:10]([CH2:11][S:12][CH3:13])=[C:9]2[C:5]([C:6]([CH:14]([C:21]3[CH:22]=[CH:23][C:24]([C:27]([F:30])([F:28])[F:29])=[CH:25][CH:26]=3)[CH2:15][CH2:16][OH:17])=[CH:7][NH:8]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 58392130Ethyl 3-{6-fluoro-7[(methylsulfanyl)methyl]-1H-indol-3-yl}-3-[4-(trifluoromethyl)phenyl]propanoateHCID 583923413-(4-Chlorophenyl)-3-{6-fluoro-7-[(methylsulfanyl)methyl]-1H-indol-3-yl}propan-1-ol

Product 1

HCID 583924883-{6-Fluoro-7-[(methylsulfanyl)methyl]-1H-indol-3-yl}-3-[4-(trifluoromethyl)phenyl]propan-1-ol

Procedure

The title compound was prepared starting from 2.98 g (6.78 mmol) of the compound from Example 48A in analogy to the synthesis of the compound from Example 16. 2.47 g (92% of theory) of the title compound were obtained.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-16afa9b8973847afb63881231f74c18a
Source dataset
uspto-grants-2011_11
Patent number
US08063234B2

Reaction notes

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