HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-{6-fluoro-7[(methylsulfanyl)methyl]-1H-indol-3-yl}-3-[4-(trifluoromethyl)phenyl]propanoate → 3-{6-Fluoro-7-[(methylsulfanyl)methyl]-1H-indol-3-yl}-3-[4-(trifluoromethyl)phenyl]propan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-{6-fluoro-7[(methylsulfanyl)methyl]-1H-indol-3-yl}-3-[4-(trifluoromethyl)phenyl]propanoate | HCID 58392130 | — |
| Reactant | 3-(4-Chlorophenyl)-3-{6-fluoro-7-[(methylsulfanyl)methyl]-1H-indol-3-yl}propan-1-ol | HCID 58392341 | — |
| Product | 3-{6-Fluoro-7-[(methylsulfanyl)methyl]-1H-indol-3-yl}-3-[4-(trifluoromethyl)phenyl]propan-1-ol | HCID 58392488 | — |
Reaction Steps
The title compound was prepared starting from 2.98 g (6.78 mmol) of the compound from Example 48A in analogy to the synthesis of the compound from Example 16. 2.47 g (92% of theory) of the title compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063234B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-16afa9b8973847afb63881231f74c18a |
| Source note | uspto-grants-2011_11 |