HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 561581Generated: October 27, 2026
3-[1-Cyclopropyl-1-(4-fluorophenyl)ethyl]-7-[(methylsulfanyl)methyl]-1H-indole → 3-[1-(4-Chloro-2-fluorophenyl)-1-cyclopropylethyl]-5-fluoro-7-[(methylsulfanyl)methyl]-1H-indole
https://huagongshe.com/reaction/561581
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3-[1-Cyclopropyl-1-(4-fluorophenyl)ethyl]-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392106 | — |
| Reactant | 3-(2,4-Dichlorophenyl)-3-{5-fluoro-7-[(methylsulfanyl)methyl]-1H-indol-3-yl}propan-1-ol | HCID 58392305 | — |
| Reactant | 1-(4-Chloro-2-fluorophenyl)-1-cyclopropylethanol | HCID 58392343 | — |
| Product | 3-[1-(4-Chloro-2-fluorophenyl)-1-cyclopropylethyl]-5-fluoro-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392156 | — |
Reaction Steps
The title compound was prepared starting from 500 mg (2.56 mmol) of the compound from Example 8 and 605 mg (2.82 mmol) of the compound from Example 79A in analogy to the synthesis of the compound from Example 95. As a difference, the reaction mixture was stirred at 0° C. for 2 h and then warmed to RT. 67 mg (7% of theory) of the target compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08063234B2 |
|---|
| Source dataset | uspto-grants-2011_11 |
|---|
| ORD ID | ord-23628267831947238aa8f5deefabb739 |
|---|
| Source note | uspto-grants-2011_11 |
|---|
