HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[(4-Fluoro-2-methylphenyl)(4-fluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole → 3-[(2,4-Difluorophenyl)(4-fluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[(4-Fluoro-2-methylphenyl)(4-fluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole | HCID 44595236 | — |
| Reactant | (2,4-Difluorophenyl)(4-fluorophenyl)methanol | HCID 58392299 | — |
| Reactant | 3-(2,4-Dichlorophenyl)-3-{5-fluoro-7-[(methylsulfanyl)methyl]-1H-indol-3-yl}propan-1-ol | HCID 58392305 | — |
| Product | 3-[(2,4-Difluorophenyl)(4-fluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392195 | — |
Reaction Steps
The title compound was prepared starting from 350 mg (1.97 mmol) of the compound from Example 8 and 470 mg (1.97 mmol) of the compound from Example 84A in analogy to the synthesis of the compound from Example 101. 191 mg (24% of theory) of the target compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063234B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-9fdc8652a0c748bca5edb1e079dae04d |
| Source note | uspto-grants-2011_11 |