3-[1-Cyclopropyl-1-(2,4-difluorophenyl)ethyl]-7-[(methylsulfanyl)methyl]-1H-indole → 3-[1-Cyclopropyl-1-(2,4-difluorophenyl)ethyl]-7-[(methylsulfinyl)methyl]-1H-indole

HRID 561592Notes

Reaction equation

HRID 561592 reaction equation
[CH:1]1([C:4]([C:14]2[C:22]3[C:17](=[C:18]([CH2:23][S:24][CH3:25])[CH:19]=[CH:20][CH:21]=3)[NH:16][CH:15]=2)([C:6]2[CH:11]=[CH:10][C:9]([F:12])=[CH:8][C:7]=2[F:13])[CH3:5])[CH2:3][CH2:2]1.CC(C(C1C2C(=C(CS(C)=[O:53])C=CC=2)NC=1)C1C=CC(C(F)(F)F)=CC=1)CC#N>>[CH:1]1([C:4]([C:14]2[C:22]3[C:17](=[C:18]([CH2:23][S:24]([CH3:25])=[O:53])[CH:19]=[CH:20][CH:21]=3)[NH:16][CH:15]=2)([C:6]2[CH:11]=[CH:10][C:9]([F:12])=[CH:8][C:7]=2[F:13])[CH3:5])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 583923223-[1-Cyclopropyl-1-(2,4-difluorophenyl)ethyl]-7-[(methylsulfanyl)methyl]-1H-indoleHCID 583923243-Methyl-4-{7-[(methylsulfinyl)methyl]-1H-indol-3-yl}-4-[4-(trifluoromethyl)phenyl]butanonitrile

Product 1

HCID 583922813-[1-Cyclopropyl-1-(2,4-difluorophenyl)ethyl]-7-[(methylsulfinyl)methyl]-1H-indole

Procedure

The title compound was prepared starting from 217 mg (94% purity, 0.61 mmol) of the compound from Example 96 in analogy to the synthesis of the compound from Example 91. 212 mg (99% of theory) of the target compound were obtained as mixture of diastereomers.

Workup

  1. custom212 mg (99% of theory) of the target compound were obtained as mixture of diastereomers

Sources & evidence

ORD record
ord-01fc6e2b037a4b0f8d59da977f31e00e
Source dataset
uspto-grants-2011_11
Patent number
US08063234B2

Reaction notes

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