HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[1-Cyclopropyl-1-(2,4-difluorophenyl)ethyl]-7-[(methylsulfanyl)methyl]-1H-indole → 3-[1-Cyclopropyl-1-(2,4-difluorophenyl)ethyl]-7-[(methylsulfinyl)methyl]-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[1-Cyclopropyl-1-(2,4-difluorophenyl)ethyl]-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392322 | — |
| Reactant | 3-Methyl-4-{7-[(methylsulfinyl)methyl]-1H-indol-3-yl}-4-[4-(trifluoromethyl)phenyl]butanonitrile | HCID 58392324 | — |
| Product | 3-[1-Cyclopropyl-1-(2,4-difluorophenyl)ethyl]-7-[(methylsulfinyl)methyl]-1H-indole | HCID 58392281 | — |
Reaction Steps
The title compound was prepared starting from 217 mg (94% purity, 0.61 mmol) of the compound from Example 96 in analogy to the synthesis of the compound from Example 91. 212 mg (99% of theory) of the target compound were obtained as mixture of diastereomers.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063234B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-01fc6e2b037a4b0f8d59da977f31e00e |
| Source note | uspto-grants-2011_11 |