反应详情

温度

0 °C

231 mg (0.59 mmol) of the compound from Example 153 were introduced into 40 ml of dichloromethane at 0° C., 198 mg (0.81 mmol) of 70% pure meta-chloroperbenzoic acid were added, and the mixture was stirred at 0° C. for 2 h. 2 ml of methanol were added, and the solution was concentrated. The residue was taken up in ethyl acetate and washed with saturated aqueous sodium bicarbonate solution, water and saturated aqueous sodium chloride solution, and the solvents were removed in a rotary evaporator. The crude product was purified by preparative HPLC (mobile phase: acetonitrile/water gradient) to result in 171 mg (71% of theory) of the title compound as mixture of diastereomers.

1. concentrationthe solution was concentrated
2. washwashed with saturated aqueous sodium bicarbonate solution, water and saturated aqueous sodium chloride solution
3. customthe solvents were removed in a rotary evaporator
4. customThe crude product was purified by preparative HPLC (mobile phase: acetonitrile/water gradient)