HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenemethanol, alpha-cyclopropyl-alpha-methyl-4-(trifluoromethyl)- → 3-{1-Cyclopropyl-1-[4-(trifluoromethyl)phenyl]ethyl}-7-[(methylsulfanyl)methyl]-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenemethanol, alpha-cyclopropyl-alpha-methyl-4-(trifluoromethyl)- | HCID 23255822 | — |
| Reactant | 7-[(Methylsulfanyl)methyl]-1H-indole | HCID 58392187 | — |
| Reactant | 3-[1-(4-Chlorophenyl)-1-cyclopropylethyl]-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392290 | — |
| Product | 3-{1-Cyclopropyl-1-[4-(trifluoromethyl)phenyl]ethyl}-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392190 | — |
Reaction Steps
The title compound was prepared starting from 462 mg (2.61 mmol) of the compound from Example 8A and 600 mg (2.61 mmol) of the compound from Example 139A in analogy to the synthesis of the compound from Example 184. 273 mg (27% of theory) of the target compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063234B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-7fc8426b095e48da80055c39e77035f8 |
| Source note | uspto-grants-2011_11 |