HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-[(Methylsulfanyl)methyl]-1H-indole → 3-[1-Cyclopropyl-1-(2,2-difluoro-1,3-benzodioxol-5-yl)ethyl]-7-[(methylsulfanyl)methyl]-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-[(Methylsulfanyl)methyl]-1H-indole | HCID 58392187 | — |
| Reactant | 3-[1-Cyclopropyl-1-(3-fluoro-4-methoxyphenyl)ethyl]-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392330 | — |
| Reactant | 1-Cyclopropyl-1-(2,2-difluoro-1,3-benzodioxol-5-yl)ethanol | HCID 58392505 | — |
| Product | 3-[1-Cyclopropyl-1-(2,2-difluoro-1,3-benzodioxol-5-yl)ethyl]-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392217 | — |
Reaction Steps
The title compound was prepared starting from 32 mg (0.18 mmol) of the compound from Example 8A and 43 mg (0.18 mmol) of the compound from Example 144A in analogy to the synthesis of the compound from Example 186. 38 mg (53% of theory) of the target compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063234B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-797e3b9332814d2ab138c8f12ca642d9 |
| Source note | uspto-grants-2011_11 |