HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-[(Methylsulfanyl)methyl]-1H-indole → 3-[1-(4-Chlorophenyl)-1-cyclopropylpropyl]-7-[(methylsulfanyl)methyl]-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-[(Methylsulfanyl)methyl]-1H-indole | HCID 58392187 | — |
| Reactant | 3-[1-Cyclopropyl-1-(3-fluoro-4-methoxyphenyl)ethyl]-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392330 | — |
| Reactant | 1-Cyclopropyl-1-(4-chlorophenyl)propanol | HCID 58392507 | — |
| Product | 3-[1-(4-Chlorophenyl)-1-cyclopropylpropyl]-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392118 | — |
Reaction Steps
The title compound was prepared starting from 84 mg (0.48 mmol) of the compound from Example 8A and 100 mg (0.48 mmol) of the compound from Example 145A in analogy to the synthesis of the compound from Example 186. 38 mg (21% of theory) of the target compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063234B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-6b98884d3c924f6f9e7ed9854d2eac07 |
| Source note | uspto-grants-2011_11 |