3-{1-Cyclopropyl-1-[4-(trifluoromethyl)phenyl]ethyl}-7-[(methylsulfanyl)methyl]-1H-indole → 3-{1-Cyclopropyl-1-[4-(trifluoromethyl)phenyl]ethyl}-7-[(methylsulfonyl)methyl]-1H-indole

HRID 561647Notes

Reaction equation

HRID 561647 reaction equation
C1(C(C2C3C(=C(CSC)C=CC=3)NC=2)(C2C=CC([C:12]([F:15])([F:14])[F:13])=CC=2)C)CC1.Cl[C:29]1[CH:34]=[CH:33][C:32]([C:35]([C:40]2[C:48]3[C:43](=[C:44]([CH2:49][S:50]([CH3:53])(=[O:52])=[O:51])[CH:45]=[CH:46][CH:47]=3)[NH:42][CH:41]=2)([CH:37]2[CH2:39][CH2:38]2)[CH3:36])=[CH:31][CH:30]=1>>[CH:37]1([C:35]([C:40]2[C:48]3[C:43](=[C:44]([CH2:49][S:50]([CH3:53])(=[O:52])=[O:51])[CH:45]=[CH:46][CH:47]=3)[NH:42][CH:41]=2)([C:32]2[CH:33]=[CH:34][C:29]([C:12]([F:15])([F:14])[F:13])=[CH:30][CH:31]=2)[CH3:36])[CH2:39][CH2:38]1

Participants

3

Reactant 2

HCID 583921903-{1-Cyclopropyl-1-[4-(trifluoromethyl)phenyl]ethyl}-7-[(methylsulfanyl)methyl]-1H-indoleHCID 583923883-[1-(4-Chlorophenyl)-1-cyclopropylethyl]-7-[(methylsulfonyl)methyl]-1H-indole

Product 1

HCID 583924683-{1-Cyclopropyl-1-[4-(trifluoromethyl)phenyl]ethyl}-7-[(methylsulfonyl)methyl]-1H-indole

Procedure

The title compound was prepared starting from 153 mg (0.39 mmol) of the compound from Example 185 in analogy to the synthesis of the compound from Example 209. 63 mg (38% of theory) of the target compound were obtained.

Workup

  1. custom63 mg (38% of theory) of the target compound were obtained

Sources & evidence

ORD record
ord-7ad6a9d6426d4d11926fc1e4a73e5a62
Source dataset
uspto-grants-2011_11
Patent number
US08063234B2

Reaction notes

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