3-[1-Cyclopropyl-1-(2,2-difluoro-1,3-benzodioxol-5-yl)ethyl]-7-[(methylsulfanyl)methyl]-1H-indole → 3-[1-Cyclopropyl-1-(2,2-difluoro-1,3-benzodioxol-5-yl)ethyl]-7-[(methylsulfonyl)methyl]-1H-indole

HRID 561651Notes

Reaction equation

HRID 561651 reaction equation
C1(C(C2C3C(=C(CSC)C=CC=3)NC=2)(C2C=CC3[O:10][C:11]([F:14])([F:13])[O:12]C=3C=2)C)CC1.Cl[C:30]1[CH:35]=[CH:34][C:33]([C:36]([C:41]2[C:49]3[C:44](=[C:45]([CH2:50][S:51]([CH3:54])(=[O:53])=[O:52])[CH:46]=[CH:47][CH:48]=3)[NH:43][CH:42]=2)([CH:38]2[CH2:40][CH2:39]2)[CH3:37])=[CH:32][CH:31]=1>>[CH:38]1([C:36]([C:41]2[C:49]3[C:44](=[C:45]([CH2:50][S:51]([CH3:54])(=[O:53])=[O:52])[CH:46]=[CH:47][CH:48]=3)[NH:43][CH:42]=2)([C:33]2[CH:34]=[CH:35][C:30]3[O:10][C:11]([F:14])([F:13])[O:12][C:31]=3[CH:32]=2)[CH3:37])[CH2:40][CH2:39]1

Participants

3

Reactant 2

HCID 583922173-[1-Cyclopropyl-1-(2,2-difluoro-1,3-benzodioxol-5-yl)ethyl]-7-[(methylsulfanyl)methyl]-1H-indoleHCID 583923883-[1-(4-Chlorophenyl)-1-cyclopropylethyl]-7-[(methylsulfonyl)methyl]-1H-indole

Product 1

HCID 583925003-[1-Cyclopropyl-1-(2,2-difluoro-1,3-benzodioxol-5-yl)ethyl]-7-[(methylsulfonyl)methyl]-1H-indole

Procedure

The title compound was prepared starting from 33 mg (0.08 mmol) of the compound from Example 190 in analogy to the synthesis of the compound from Example 209. 27 mg (76% of theory) of the target compound were obtained.

Workup

  1. custom27 mg (76% of theory) of the target compound were obtained

Sources & evidence

ORD record
ord-7a211d3d4dbc424aabb1b2fd18528c3a
Source dataset
uspto-grants-2011_11
Patent number
US08063234B2

Reaction notes

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