HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[1-Cyclopropyl-1-(2,2-difluoro-1,3-benzodioxol-5-yl)ethyl]-7-[(methylsulfanyl)methyl]-1H-indole → 3-[1-Cyclopropyl-1-(2,2-difluoro-1,3-benzodioxol-5-yl)ethyl]-7-[(methylsulfonyl)methyl]-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[1-Cyclopropyl-1-(2,2-difluoro-1,3-benzodioxol-5-yl)ethyl]-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392217 | — |
| Reactant | 3-[1-(4-Chlorophenyl)-1-cyclopropylethyl]-7-[(methylsulfonyl)methyl]-1H-indole | HCID 58392388 | — |
| Product | 3-[1-Cyclopropyl-1-(2,2-difluoro-1,3-benzodioxol-5-yl)ethyl]-7-[(methylsulfonyl)methyl]-1H-indole | HCID 58392500 | — |
Reaction Steps
The title compound was prepared starting from 33 mg (0.08 mmol) of the compound from Example 190 in analogy to the synthesis of the compound from Example 209. 27 mg (76% of theory) of the target compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063234B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-7a211d3d4dbc424aabb1b2fd18528c3a |
| Source note | uspto-grants-2011_11 |