HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[(4-Chlorophenyl)(cyclopropyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole → 3-[(2-Chloro-4-fluorophenyl)(cyclopropyl)methyl]-5-fluoro-7-[(methylsulfanyl) methyl]-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[(4-Chlorophenyl)(cyclopropyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392138 | — |
| Reactant | 5-Fluoro-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392227 | — |
| Reactant | (4-Chloro-2,6-difluorophenyl)(cyclopropyl)methanol | HCID 58392245 | — |
| Product | 3-[(2-Chloro-4-fluorophenyl)(cyclopropyl)methyl]-5-fluoro-7-[(methylsulfanyl) methyl]-1H-indole | HCID 58392422 | — |
Reaction Steps
The title compound was prepared starting from 200 mg (1.02 mmol) of the compound from Example 11A and 206 mg (1.02 mmol) of the compound from Example 156A in analogy to the synthesis of the compound from Example 227. 247 mg (64% of theory) of the target compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063234B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-75be6ef4c98644fbb6c6807574c0d6b1 |
| Source note | uspto-grants-2011_11 |