HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-alpha-cyclopropylbenzenemethanol → 3-[(4-Chlorophenyl)(cyclopropyl)methyl]-6-fluoro-7-[(methylsulfanyl)methyl]-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-alpha-cyclopropylbenzenemethanol | HCID 86679 | — |
| Reactant | 6-Fluoro-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392259 | — |
| Reactant | 3-[(2-Chloro-4-fluorophenyl)(cyclopropyl)methyl]-6-fluoro-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392412 | — |
| Product | 3-[(4-Chlorophenyl)(cyclopropyl)methyl]-6-fluoro-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392376 | — |
Reaction Steps
The title compound was prepared starting from 500 mg (2.56 mmol) of the compound from Example 9A and 468 mg (2.56 mmol) of the compound from Example 153A in analogy to the synthesis of the compound from Example 233. 411 mg (44% of theory) of the target compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063234B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-2239be35a4a0473888e3f35ed2732490 |
| Source note | uspto-grants-2011_11 |