反应详情

温度

0 °C

To anhydrous THF (70 mL) was added LiAlH4 (5.37 g, 142 mmol) in one portion. The mixture was stirred at 0° C. for 20 min, and a solution of 4-morpholinobutanenitrile (7.26 g, 47 mmol) in anhydrous THF (40 mL) was added dropwise. Upon the end of addition the mixture was refluxed for 4 h, then cooled to 0° C., diluted with water (20 mL) and filtered. The filtrate was concentrated in vacuo to give the crude product for the next step without further purification.

1. additionUpon the end of addition the mixture
2. temperaturewas refluxed for 4 h
3. temperaturecooled to 0° C.
4. filtrationfiltered
5. concentrationThe filtrate was concentrated in vacuo