HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[(4-Fluorophenyl)(hydroxy)methyl]benzonitrile → 4-[(4-Fluorophenyl){7-[(methylsulfanyl)methyl]-1H-indol-3-yl}methyl]benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[(4-Fluorophenyl)(hydroxy)methyl]benzonitrile | HCID 11183755 | — |
| Reactant | 3-[Bis(4-fluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392127 | — |
| Reactant | 7-[(Methylsulfanyl)methyl]-1H-indole | HCID 58392187 | — |
| Product | 4-[(4-Fluorophenyl){7-[(methylsulfanyl)methyl]-1H-indol-3-yl}methyl]benzonitrile | HCID 67000852 | — |
Reaction Steps
The title compound was prepared starting from 750 mg (4.23 mmol) of the compound from Example 8A and 961 mg (4.23 mmol) of the compound from Example 173A in analogy to the synthesis of the compound from Example 278. 276 mg (17% of theory) of the target compound were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08063234B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-12ed8453ad1f4542b75c3e35472d1325 |
| Source note | uspto-grants-2011_11 |