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HRID 561708作成日：2026年10月25日
(4-Chlorophenyl)(4-fluorophenyl)methanol → 3-[(4-Chlorophenyl)(4-fluorophenyl)methyl]-5-fluoro-7-[(methylsulfanyl)methyl]-1H-indole
https://huagongshe.com/reaction/561708
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | (4-Chlorophenyl)(4-fluorophenyl)methanol | HCID 12634874 | — |
| 反応物 | 3-[Bis(4-fluorophenyl)methyl]-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392127 | — |
| 反応物 | 5-Fluoro-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392227 | — |
| 生成物 | 3-[(4-Chlorophenyl)(4-fluorophenyl)methyl]-5-fluoro-7-[(methylsulfanyl)methyl]-1H-indole | HCID 58392172 | — |
反応手順
The title compound was prepared starting from 500 mg (2.56 mmol) of the compound from Example 11A and 667 mg (2.56 mmol) of the compound from Example 81A in analogy to the synthesis of the compound from Example 278. A difference was that stirring at 80° C. was for only 4 h. 535 mg (50% of theory) of the target compound were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08063234B2 |
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| 出典データセット | uspto-grants-2011_11 |
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| ORD ID | ord-96b97a45989947df83e8d72184099e7e |
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| 出典メモ | uspto-grants-2011_11 |
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