HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-(3-ethoxypropyl)-2-fluoro-4-nitroaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Propanolamine ethyl ether | HCID 22720 | — |
| Reactant | 1,2-Difluoro-4-nitrobenzene | HCID 123053 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | N-(3-ethoxypropyl)-2-fluoro-4-nitroaniline | HCID 28972577 | 90% |
Reaction Steps
To a solution of 3,4-difluoronitrobenzene (6.36 g, 40 mmol) in EtOAc (60 mL) were added Et3N (12.14 g, 120 mmol) and 3-ethoxypropan-1-amine (4.54 g, 44 mmol). The reaction mixture was refluxed overnight, then cooled to rt and concentrated in vacuo to give the title compound as yellow oil (8.68 g, 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434695B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-c1932aaead9146289c1cb1541dfbdc8b |
| Source note | uspto-grants-2016_09 |