2-Butenoic acid, 3-(acetylamino)-, methyl ester, (2Z)- → HCID 72950003, compound
Reaction equation
[CH2:1]([O:3][CH2:4][CH2:5][CH2:6][NH:7][C:8]1[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][C:9]=1[F:15])[CH3:2].C[Al](C)C.[NH:20](/[C:24](/[CH3:30])=[CH:25]\[C:26](OC)=[O:27])[C:21]([CH3:23])=O>C(Cl)Cl>[CH2:1]([O:3][CH2:4][CH2:5][CH2:6][NH:7][C:8]1[CH:13]=[CH:12][C:11]([N:14]2[C:26](=[O:27])[CH:25]=[C:24]([CH3:30])[N:20]=[C:21]2[CH3:23])=[CH:10][C:9]=1[F:15])[CH3:2]Participants
Procedure
To a solution of N1-(3-ethoxypropyl)-2-fluorobenzene-1,4-diamine (5.52 g, 26 mmol) in CH2Cl2 (40 mL) was added trimethylaluminium (52 mL, 104 mmol, 2 M in toluene) slowly. The mixture was stirred at rt for 0.5 h, followed by the addition of a solution of methyl 3-acetaminocrotonate (4.87 g, 31 mmol) in CH2Cl2 (10 mL). The reaction mixture was stirred at rt for 72 h, then quenched with saturated NH4Cl aqueous solution and extracted with CH2Cl2 (150 mL×3). The combined organic phases were washed with brine, dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1) to give the title compound as pale yellow oil (2.22 g, 27%). The compound was characterized by the following spectroscopic data:
Workup
- stirringThe reaction mixture was stirred at rt for 72 h
- customquenched with saturated NH4Cl aqueous solution
- extractionextracted with CH2Cl2 (150 mL×3)
- washThe combined organic phases were washed with brine
- dry with materialdried over anhydrous Na2SO4
- concentrationconcentrated in vacuo
- customThe residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1)
Sources & evidence
- ORD record
- ord-480fe4e83a7a401296546e89e8bd87d7
- Source dataset
- uspto-grants-2016_09
- Patent number
- US09434695B2
Reaction notes
Loading…