反应详情

To a solution of N-cyclopropyl-2,6-bis[(1E)-3-methoxyprop-1-en-1-yl]isonicotinamide from the previous step (1 eq.) in EtOAc (0.2 M) was added palladium (10% w/w over activated carbon, 40% loading). The reaction vessel was evacuated and back-filled with hydrogen. The reaction suspension was then stirred under a balloon atmosphere of hydrogen for 24 h. The reaction was quenched with CH2Cl2, filtered through celite and the insolubles washed further with EtOAc. Concentration of the filtrate in vacuo and purification of the crude product thus obtained by way of column chromatography (SiO2, 1:1 (v/v) Hex:EtOAc→1:4 (v/v) Hex:EtOAc) afforded the title compound as a colorless oil.

1. customThe reaction vessel was evacuated
2. additionback-filled with hydrogen
3. customThe reaction was quenched with CH2Cl2
4. filtrationfiltered through celite
5. washthe insolubles washed further with EtOAc
6. customConcentration of the filtrate in vacuo and purification of the crude product
7. customthus obtained by way of column chromatography (SiO2, 1:1 (v/v) Hex:EtOAc→1:4 (v/v) Hex:EtOAc)