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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 56185Generated: October 29, 2026

(2-Fluoro-4-nitrophenyl)-(3-imidazol-1-ylpropyl)amine → HCID 28993591, compound

https://huagongshe.com/reaction/56185

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2-Fluoro-4-nitrophenyl)-(3-imidazol-1-ylpropyl)amineHCID 18003903—
CatalystPalladiumHCID 23938—
SolventTetrahydrofuranHCID 8028—
ProductHCID 28993591HCID 2899359194%

Reaction Steps

To a solution of N-(3-(1H-imidazol-1-yl)propyl)-2-fluoro-4-nitroaniline (1.20 g, 4.54 mmol) in THF (20 mL) was added catalyst Pd/C (0.30 g). The reaction mixture was stirred at rt under H2 overnight. The mixture was filtered, and the filtrate was concentrated in vacuo to give the title compound as yellow oil (1.00 g, 94%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09434695B2
Source datasetuspto-grants-2016_09
ORD IDord-79030226c78847ccb382db9e40140f39
Source noteuspto-grants-2016_09