(2-Fluoro-4-nitrophenyl)-(3-imidazol-1-ylpropyl)amine → HCID 28993591, compound

HRID 56185Notes

Reaction equation

HRID 56185 reaction equation
[N:1]1([CH2:6][CH2:7][CH2:8][NH:9][C:10]2[CH:15]=[CH:14][C:13]([N+:16]([O-])=O)=[CH:12][C:11]=2[F:19])[CH:5]=[CH:4][N:3]=[CH:2]1>C1COCC1.[Pd]>[N:1]1([CH2:6][CH2:7][CH2:8][NH:9][C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][C:11]=2[F:19])[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 1

HCID 18003903(2-Fluoro-4-nitrophenyl)-(3-imidazol-1-ylpropyl)amine

Product 1

HCID 28993591HCID 28993591, compoundYield 94%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of N-(3-(1H-imidazol-1-yl)propyl)-2-fluoro-4-nitroaniline (1.20 g, 4.54 mmol) in THF (20 mL) was added catalyst Pd/C (0.30 g). The reaction mixture was stirred at rt under H2 overnight. The mixture was filtered, and the filtrate was concentrated in vacuo to give the title compound as yellow oil (1.00 g, 94%).

Workup

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-79030226c78847ccb382db9e40140f39
Source dataset
uspto-grants-2016_09
Patent number
US09434695B2

Reaction notes

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