反应详情

To a solution of 2-fluoro-4-nitro-N-(2-(piperidin-1-yl)ethyl)aniline (1.87 g, 7.00 mmol) in THF (20 mL) was added catalyst Pd/C (0.50 g). The reaction mixture was stirred at rt under H2 overnight. The mixture was filtered, and the filtrate was concentrated in vacuo. The residue was purified by a silica gel column chromatography (DCM/MeOH (V/V)=15:1) to give the title compound as yellow oil (1.50 g, 90%).

1. filtrationThe mixture was filtered
2. concentrationthe filtrate was concentrated in vacuo
3. customThe residue was purified by a silica gel column chromatography (DCM/MeOH (V/V)=15:1)