Hydrochloric Acid → HCID 178494886, compound

HRID 561884Notes

Reaction equation

HRID 561884 reaction equation
[Si]([O:8][C:9]1[CH:14]=[C:13]([CH2:15][N:16]([CH:49]2[CH2:51][CH2:50]2)[C:17](=[O:48])[CH:18]([CH2:28][C:29]2[CH:34]=[CH:33][C:32]([O:35][CH2:36][CH2:37][O:38][C:39]3[C:44]([Cl:45])=[CH:43][C:42]([CH3:46])=[CH:41][C:40]=3[Cl:47])=[CH:31][CH:30]=2)[CH2:19][NH:20]C(=O)OC(C)(C)C)[CH:12]=[C:11]([CH2:52][CH2:53][CH2:54][O:55][CH3:56])[N:10]=1)(C(C)(C)C)(C)C.Cl>C(Cl)Cl>[NH2:20][CH2:19][CH:18]([CH2:28][C:29]1[CH:34]=[CH:33][C:32]([O:35][CH2:36][CH2:37][O:38][C:39]2[C:40]([Cl:47])=[CH:41][C:42]([CH3:46])=[CH:43][C:44]=2[Cl:45])=[CH:31][CH:30]=1)[C:17]([N:16]([CH:49]1[CH2:50][CH2:51]1)[CH2:15][C:13]1[CH:12]=[C:11]([CH2:52][CH2:53][CH2:54][O:55][CH3:56])[N:10]=[C:9]([OH:8])[CH:14]=1)=[O:48]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86635943Tert-butyl (3-[{[2-{[tert-butyl(dimethyl)silyl]oxy}-6-(3-methoxypropyl)pyridin-4-yl]methyl}(cyclopropyl)amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate

Product 1

HCID 178494886HCID 178494886, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a CH2Cl2 solution (0.03 M) of tert-butyl (3-[{[2-{[tert-butyl(dimethyl)silyl]oxy}-6-(3-methoxypropyl)pyridin-4-yl]methyl}(cyclopropyl)amino]-2-{4-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]benzyl}-3-oxopropyl)carbamate from the previous step (1 eq.) was added HCl (4.0 M dioxane solution, 60 eq.). The resulting solution was stirred at RT for 3 h and the volatiles were removed in vacuo. The resulting residue was recrystallized from ether-dichloromethane to afford the title compound as a white solid. MS (ESI+): 616.1.

Workup

  1. customthe volatiles were removed in vacuo
  2. customThe resulting residue was recrystallized from ether-dichloromethane

Sources & evidence

ORD record
ord-333c67b7c7634db0ae1968331d4e62bb
Source dataset
uspto-grants-2011_11
Patent number
US08063105B2

Reaction notes

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