huagongshe.com
HRID561994

反应详情

EQUATION

反应方程式

HRID 561994 的结构方程式

REACTANTS

反应物

4
结构：O=C1CCC(=O)N1Cl
HCID31398

N-Chlorosuccinimide

C4H4ClNO2

结构：CC(C)[C@@H](c1ncc(-c2ccc(I)cc2)[nH]1)N1C(=O)N[C@H](CCC(=O)O)C1=O
HCID57771978

未命名化合物

结构：CN(C)C(=O)COc1ccc([C@@H](NC(=O)OC(C)(C)C)C(=O)O)cc1
HCID66815126

未命名化合物

2 次

结构：Cc1nc([C@H]([C@@H](C)c2ccccc2)N2C(=O)N[C@H](CC3CC3)C2=O)[nH]c1-c1ccc(I)cc1F
HCID178432851

未命名化合物

PRODUCTS

生成物

1
结构：Cc1nc([C@H]([C@@H](C)c2ccccc2)N2C(=O)N[C@H](c3ccc(OCC(=O)N(C)C)cc3)C2=O)[nH]c1-c1ccc(I)cc1F
HCID178432850

未命名化合物

PROCEDURE

实验过程

Prepared by the same method as described in example 1 except that (i) steps A, B and C were omitted; (ii) 1-(2-fluoro-4-iodo-phenyl)-propan-1-one (prepared as described in example 13) was used in place of 1-(2-fluoro-4-iodo-phenyl)-ethanone in step 72-D; (iii) chlorination of the 5-position of the imidazole ring with N-chlorosuccinimide in step 72-F was omitted and (iv) (R)-tert-butoxycarbonylamino-(4-dimethylcarbamoylmethoxy-phenyl)-acetic acid (prepared as described in example 6) was used in place of (R)-tert-butoxycarbonylamino-[4-(2-tert-butoxy-ethoxy)-phenyl]-acetic acid in step 72-G. HR-MS: calcd for C32H31FlN5O4 [M+H+] 696.1478. Found 696.1475.

WORKUP

后处理

  1. customPrepared by the same method