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HRID561999

反应详情

EQUATION

反应方程式

HRID 561999 的结构方程式

REACTANTS

反应物

4
结构：O=C1CCC(=O)N1Cl
HCID31398

N-Chlorosuccinimide

C4H4ClNO2

结构：CC(C)[C@@H](c1ncc(-c2ccc(I)cc2)[nH]1)N1C(=O)N[C@H](CCC(=O)O)C1=O
HCID57771978

未命名化合物

结构：CN(C)C(=O)COc1ccc([C@@H](NC(=O)OC(C)(C)C)C(=O)O)cc1
HCID66815126

未命名化合物

结构：Cc1nc([C@H]([C@@H](C)c2ccccc2)N2C(=O)N[C@H](CC3CC3)C2=O)[nH]c1-c1ccc(I)cc1F
HCID178432851

未命名化合物

PRODUCTS

生成物

1
结构：CCC[C@@H](c1ncc(-c2ccc(I)cc2Cl)[nH]1)N1C(=O)N[C@H](c2ccc(OCCO)cc2)C1=O
HCID57771946

未命名化合物

PROCEDURE

实验过程

Prepared by the same method as described in example 1 except that (i) 2-chloro-1,4-diiodo-benzene was used in place of 2-fluoro-1,4-diiodo-benzene in step 80-A; (ii) (S)-2-tert-butoxycarbonylamino-pentanoic acid was used in place of (2S,3S)-2-tert-butoxycarbonylamino-3-phenyl-butyric acid in step 80-E; (iii) chlorination of the 5-position of the imidazole ring with N-chlorosuccinimide in step 80-F was omitted and (iv) removal of protecting groups and cyclization to form the hydantoin in step 80-H was performed as described in step 34-H. HR-MS: calcd for C24H24ClIN4O4 [M+H+] 595.0604. Found 595.0603.

WORKUP

后处理

  1. customPrepared by the same method
  2. custom(iv) removal of protecting groups and cyclization